Published in biorxiv, 2026
We build a better statistical tool for MPRAs.
Recommended citation: Albert Xue, Adam M Zahm, Justin English, Sriram Sankararaman, and Harold Pimentel (2026). "keju: powerful and accurate inference in Massively Parallel Reporter Assays." biorxiv.
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Published in Nature Genetics, 2025
We learn marginal epistasis in the UK Biobank.
Recommended citation: Boyang Fu, Ali Pazokitoroudi, Zuozheng Shi, Asha Kar, Albert Xue, Akarsh Anand, Prateek Anand, Zhengtong Liu, Richard Border, Päivi Pajukanta, Noah Zaitlen, and Sriram Sankararaman (2025). "A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic epistasis." Nature Genetics.
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Published in biorxiv, 2025
We see how cells react to multiple CRISPR perturbations.
Recommended citation: Stefan Oberlin, Neil Tay, Albert Xue, Harold Pimentel, and Michael T McManus (2025). "Multiplexed Perturbation Enables Scalable Pooled Screens." biorxiv.
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Published in iScience, 2025
We learned causal gene regulatory networks using Perturb-seq data.
Recommended citation: Albert Xue, Jingyou Rao, Sriram Sankararaman, and Harold Pimentel (2025). "dotears: Scalable and consistent directed acyclic graph estimation using observational and interventional data." iScience, Volume 28, Issue 2, 111673. doi.org/10.1016/j.isci.2024.111673.
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